莽草酸脱氢酶 功能 异名 参考文献 导航菜单1.1.1.259026-87-3...
活性位点结合位点Binding site催化三联体负氧离子洞酶催化混杂Enzyme promiscuity催化最适酶Catalytically perfect enzyme辅因子辅酶酶促反应EC編號蛋白质超家族Protein superfamily蛋白质家族酶列表氧化还原酶列表List of EC numbers (EC 1)转移酶列表List of EC numbers (EC 2)水解酶列表List of EC numbers (EC 3)裂合酶列表List of EC numbers (EC 4)异构酶列表List of EC numbers (EC 5)连接酶列表List of EC numbers (EC 6)
EC 1.1.1NADH依赖性酶已知结构的酶
EC1.1.1.25NADP+受体供体CHOH基团氧化还原酶酶催化酶促反应酪氨酸色氨酸生物合成莽草酸途径生物细胞3-脱氢奎尼酸脱水酶复合物shikimate pathwaybiosynthesisphenylalaninetyrosinetryptophanessential amino acid212345672.7.1011-1289312343.4.212223245678910111213
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| 莽草酸脱氢酶结构 | |||||||||
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EC编号 | 1.1.1.25 | ||||||||
CAS号 | 9026-87-3 | ||||||||
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IntEnz | IntEnz浏览 | ||||||||
BRENDA | BRENDA入口 | ||||||||
ExPASy | NiceZyme浏览 | ||||||||
KEGG | KEGG入口 | ||||||||
MetaCyc | 代谢路径 | ||||||||
PRIAM | 概述 | ||||||||
PDB | RCSB PDB PDBj PDBe PDBsum | ||||||||
基因本体 | AmiGO / EGO | ||||||||
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莽草酸脱氢酶（英语：shikimate dehydrogenase，EC 1.1.1.25）是一种以NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：
莽草酸 + NADP+⇌{displaystyle rightleftharpoons } 3-脱氢莽草酸 + NADH + H+
上述反应中的NADP+不能以NAD+替代[1]。莽草酸脱氢酶主要参与苯丙氨酸、酪氨酸和色氨酸的生物合成过程——莽草酸途径。在较高等的生物细胞中，这种酶与3-脱氢奎尼酸脱水酶一同构成一种多酶复合物。[2]
功能
Shikimate dehydrogenase is an enzyme that catalyzes one step of the shikimate pathway. This pathway is found in bacteria, plants, fungi, algae, and parasites and is responsible for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan) from the metabolism of carbohydrates. In contrast, animals and humans lack this pathway hence products of this biosynthetic route are essential amino acids that must be obtained through an animal's diet.
There are seven enzymes that play a role in this pathway. Shikimate dehydrogenase (also known as 3-dehydroshikimate dehydrogenase) is the fourth step of the seven step process. This step converts 3-dehydroshikimate to shikimate as well as reduces NADP+ to NADPH.
异名
由于莽草酸脱氢酶催化一个可逆的氧化还原反应，且对于莽草酸碳原子编号顺序不同，所以除了它的系统名：shikimate:NADP+ 3-oxidoreductase 莽草酸：NADP+ 3-氧化还原酶之外，还存在多个异名：
- dehydroshikimic reductase 脱氢莽草酸还原酶
- shikimate oxidoreductase 莽草酸氧化还原酶
- shikimate:NADP+ oxidoreductase 莽草酸：NADP+ 氧化还原酶
- 5-dehydroshikimate reductase 5-脱氢莽草酸还原酶
- shikimate 5-dehydrogenase 莽草酸 5-脱氢酶
- 5-dehydroshikimic reductase 5-脱氢莽草酸还原酶
- DHS reductase DHS还原酶
- shikimate:NADP+ 5-oxidoreductase 莽草酸：NADP+ 5-氧化还原酶
- AroE。
参考文献
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^ Yaniv H, Gilvarg C. Aromatic biosynthesis. XIV. 5-Dehydroshikimic reductase. J. Biol. Chem. 1955, 213 (2): 787–95. PMID 14367339.
^ Chaudhuri S, Coggins JR. The purification of shikimate dehydrogenase from Escherichia coli. Biochem. J. 1985, 226 (1): 217–23. PMC 1144695. PMID 3883995.
Balinsky D, Davies DD. Aromatic biosynthesis in higher plants. 1. Preparation and properties of dehydroshikimic reductase. Biochem. J. 1961, 80 (2): 292–6. PMC 1243996. PMID 13686342.
Mitsuhashi S, Davis BD. Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase. Biochim. Biophys. Acta. 1954, 15 (2): 268–80. PMID 13208693. doi:10.1016/0006-3002(54)90069-4.
Anton IA, Coggins JR. Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase. Biochem. J. 1988, 249 (2): 319–26. PMC 1148705. PMID 3277621.
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